In mammalian cells, the nucleolus is the central site for ribosome biogenesis. It is composed of distinct subcompartments: the fibrillar center (FC), the dense fibrillar component (DFC), the periphery ...
(a) FISH of pre-18S and pre-28S rRNA in mouse early embryos. Yellow triangles indicate pre-rRNA signal within the NPB or nucleolus. Scale bar, 20 μm. (b) Fluorescence of CYTO signal in mouse early ...