Brain metabolism underpins nearly every aspect of neuronal function, from synaptic transmission and plasticity to cell survival and repair. The brain is one ...

Cholesterol is a pivotal lipid in the central nervous system, essential for membrane integrity, synaptic transmission and myelin formation. Unlike peripheral tissues, brain cholesterol is synthesised ...

(A) The volcano plot illustrating differentially expressed genes (DEGs) in the AAVT42-BDNF treatment and AAVT42-GFP hippocampus. Dotted lines highlighting the P-value = 0.05 (y-axis) and fold change = ...

Researchers at the University of California, San Francisco have identified an iron-storing protein called ferritin light chain 1 (FTL1) as a driver of age-related cognitive decline in mice, and they ...

AD is associated with significant changes in genes related to neuroinflammation, and lipids are crucial in this metabolic dysregulation. Abnormal phospholipid accumulation in the brain not only ...