The functional unit of skeletal muscle, the sarcomere, consists of a highly organized repeating pattern of contractile and regulatory proteins aligned into thick and thin filaments 1,2,3. Here, the ...

Muscle force is directly proportional to the number of myosin motors going through the cross-bridge cycle, the ATP-driven interaction between myosin proteins protruding from the thick filament and ...

An international team, led by Stefan Raunser, Director at the Max Planck Institute of Molecular Physiology in Dortmund, in collaboration with Mathias Gautel at the King's College in London, has ...

Atrial fibrillation, heart failure and stroke—hypertrophic cardiomyopathy can lead to many serious health conditions and is a major cause of sudden cardiac death in people younger than 35. "The heart ...

The standard textbook model of muscle contraction includes only two main players, the filaments actin and myosin, which slide past each other, causing the sarcomere—the basic unit of muscle tissue—to ...

The human heart, often described as the body's engine, is a remarkable organ that tirelessly beats to keep us alive. At the core of this vital organ, intricate processes occur when it contracts, where ...