Lung cancer is the leading cause of cancer death worldwide and even today only 10% of people survive lung cancer for 10 years or more in the UK. One challenge in treating lung cancer is that lung ...
Within molecular biology, few regulatory proteins have attracted as much sustained attention as P21, a cyclin-dependent ...
The study addresses the complex regulation of HSCs, highlighting p21's multifunctional nature beyond cell cycle control. Through the use of p21-tdTomato mice, researchers differentiate between p21-tdT ...
p21 interacts with Zbtb18 to co-repress the transcription of cKit in HSCs, contributing to the enhanced self-renewal ability of p21-tdT + HSCs. The study provides novel insights into the physiological ...
Ubiquitin-specific protease 7 (USP7) is involved in DNA repair and cell cycle progression and, due to its control over the ubiquitination of key proteins, may impact oncogenes like MDM2 and c-Myc, as ...
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