Oxetanes are four-membered oxygen heterocycles that have emerged as versatile motifs in drug design owing to their high ring strain, three-dimensional shape and capacity to modulate key ...

Researchers have pioneered a new catalytic transformation that converts epoxides into fluorinated oxetanes, a coveted but difficult-to-make class of drug molecules that escaped synthetic preparation ...

Researchers from the National University of Singapore (NUS) have pioneered a new catalytic transformation that converts epoxides into fluorinated oxetanes, a coveted but difficult-to-make class of ...

This novel reaction mechanism of oxetane ring formation breaks the conventional understanding that oxetane ring formation in the taxol biosynthesis pathway is achieved through a rearrangement reaction ...

Traditional ways of constructing the oxetane ring cannot directly produce α,α-difluoro-oxetanes, owing to a lack of suitable fluorine-containing precursors or reagents, or both. Furthermore, ...

The cancer drug paclitaxel has captured the imaginations of chemists for decades, in part because of its complex polycyclic core with an oxetane ring. Although scientists have synthesized the molecule ...

Researchers from NUS have pioneered a photocatalytic atom-swapping transformation that converts oxetanes into a variety of four-membered saturated cyclic molecules, which are key scaffolds in ...

A scheme showing two complex organic molecules with multiple ring systems: the one on the left contains a four-sided ring with an oxygen in it, and the one on the left is identical except that the ...

Mr Li Shuo-Han (left), Assoc Prof Koh Ming Joo (centre) and Dr Zhang Ying-Qi (right) from the Department of Chemistry at NUS were key members of the research team that developed the new atom-swapping ...